Welcome to Biothermal Cancer Detection Research Group

The Biothermal Cancer Detection Research Lab is located in the Discovery Park, University of North Texas, Denton and is directed by Dr. Tae-Youl Choi and Dr. Denise Perry Simmons. Our research is focused on cellular level thermal characterization to understand the pathogenesis of the disease and translational implications. We apply principles of materials science such as thermodynamics and heat transfer to human cells, considering “the cell as a material” combined with the biological sciences, such as the cell cycle.


November 5, 2021

Mechanical Engineering Colloquium
 “The Cell as a Material: Biomedical Applications"

To Register:

Watch for the Colloquium Updates at the Virtual-Live Transdisciplinary Ancestral Genomics Research Conference II   https://www.ancestralgenomics.org/ 

"Actively Engaging the Community, Community Health Workers & Representatives, and Researchers"


July 9, 2020

Samuel A. McCaulley, Senior TAMS Researcher receives prestigious UNT Honors College Undergraduate Research Fellow Award for his research project, "Micro-thermal Sensor (MTS): Fabrication and calibration of a next generation prototype".


July 5, 2020

Ramesh Shrestha, Ph.D.

First author publication entitled "Thermal conductivity of a Jurkat cell measured by a transient laser point heating method" has been accepted in International Journal of Heat and Mass Transfer.


June 22, 2020

AACR virtual conference proceedings

Atluri, R., Daniel, K., Tyagi, N., Kim, E., Borgmann K., Marpu, S.B., Choi, T.Y., Simmons, D.P. A potential treatment for glioblastoma multiforme: Silver nanoparticles and Low-level laser combination treatment [abstract]. In: Proceedings of the Virtual Annual Meeting II of the American Association for Cancer Research; 2020 June 22-24; AACR Virtual Annual Meeting II; 2020. Abstract nr 7835.


February 24, 2020

New way to diagnose cancer

Choi has developed a micropipette sensor technology that will allow for a quicker and more reliable diagnosis of cancerous or precancerous cells. Doctors also should be able to determine the boundary between cancerous and healthy tissue in real time during surgery rather than having to remove tissue from around a tumor for testing in a lab. 

“Instead of taking the temperature of the patient, I am sort of taking the temperature of their cells,” said Choi. “Thermal properties of healthy cells change as they become cancerous.”

January 27, 2020

TAMS transdisciplinary researcher, Eunyoung Lucy Kim, named as 2020 Regeneron top 300 high school scholars in the Nation

(From left) UNT TAMS students Lucy Kim, Nikhil Vicas, and Abhishek Joshi photographed in front of the Life Sciences building in Denton, Texas on January 24, 2019. (Photo Courtesy: Ranjani Groth/UNT Photo)

“Kim’s research was conducted to better understand nanoparticle cancer treatments. She worked closely with her UNT mentor Denise Perry Simmons in the Departments of Chemistry and Mechanical & Energy Engineering to derive a theoretical framework in development of 3D cancer treatment models and is currently working with Yuri Rostovtsev in the Department of Physics to create a mathematical model that can be used to predict the best 3D treatment design.”

Student Outreach

Dr. Simmons UNT- Texas Academy of Mathematics and Science (TAMS)

February 8, 2020

TAMS Research Fair                                                     

(From right) TAMS Research Fair Judge Dr. Denise Simmons (Photo Courtesy: Kate Liang/UNT TAMS)

September 11, 2019

TAMS Faculty Research Symposium

TAMS Faculty Research Symposium Invited Panel (Photo Courtesy: Shreya Tamma/UNT TAMS)